董夢秋

女， 北京生命科學(xué)研究所， 教授/研究員/教授級高工或同等級別

學(xué)習(xí)/工作經(jīng)歷

1992：四川大學(xué)生物系生物化學(xué)專業(yè)，學(xué)士
1995：中國科學(xué)院上海生物化學(xué)研究所，碩士
2001：美國耶魯大學(xué)，分子生物物理與生物化學(xué)系，博士
2001–2003: 美國加州大學(xué)圣迭戈分校，細(xì)胞分子醫(yī)學(xué)系，博士后
2003–2007：美國斯克利普斯研究院，博士后
2007年11月至今：北京生命科學(xué)研究所研究員

研究領(lǐng)域和興趣

生物質(zhì)譜

主要業(yè)績

董夢秋課題組開發(fā)的交聯(lián)肽段質(zhì)譜鑒定技術(shù)是輔助解析蛋白質(zhì)結(jié)構(gòu)或蛋白-蛋白相互作用的有效工具，被全球很多實(shí)驗(yàn)室采用。相關(guān)文章在Nature Methods、Nature Communications、eLife、Journal of Proteome Research、Analytical Chemistry 等期刊上發(fā)表。

代表成果

1. Wang JH?, Tang YL?, Gong Z, Jain R, Xiao F, Zhou Y, Tan D, Li Q, Huang N, Liu SQ, Ye K, Tang C*, Dong MQ*, Lei X*. (2022) Characterization of protein unfolding by fast cross-linking mass spectrometry using di-ortho-phthalaldehyde cross-linkers. Nat Commun. 13(1):1468. doi: 10.1038/s41467-022-28879-4.
2. Jones AX?, Cao Y?, Tang YL?, Wang JH, Ding YH, Tan H, Chen ZL, Fang RQ, Yin J, Chen RC, Zhu X, She Y, Huang N, Shao F, Ye K, Sun RX, He SM, Lei X*, Dong MQ*. (2019) Improving mass spectrometry analysis of protein structures with arginine-selective chemical cross-linkers. Nat Commun. 10(1):3911. doi: 10.1038/s41467-019-11917-z.
3. Chen ZL?, Meng JM?, Cao Y?, Yin JL, Fang RQ, Fan SB, Liu C, Zeng WF, Ding YH, Tan D, Wu L, Zhou WJ, Chi H, Sun RX, Dong MQ*, He SM*. (2019) A high-speed search engine pLink with systematic evaluation for proteome-scale identification of cross-linked peptides. Nat Commun. 10(1):3404. doi: 10.1038/s41467-019-11337-z.
4. Ding YH?, Gong Z?, Dong X?, Liu K, Liu Z, Liu C, He SM, Dong MQ*, Tang C*. (2017) Modeling protein excited-state structures from "over-length" chemical cross-links. J Biol Chem. 292(4):1187-1196.
5. Tan D?, Li Q?, Zhang MJ, Liu C, Ma C, Zhang P, Ding YH, Fan SB, Tao L, Yang B, Li X, Ma S, Liu J, Feng B, Liu X, Wang HW, He SM, Gao N, Ye K, Dong MQ*, Lei X*. (2016) Trifunctional cross-linker for mapping protein-protein interaction networks and comparing protein conformational states. eLife. 2016 Mar 8;5. pii: e12509. doi: 10.7554/eLife.12509.
6. Ding YH, Fan SB, Li S, Feng BY, Gao N, Ye K, He SM, Dong MQ*. (2016) Increasing the depth of mass-spectrometry-based structural analysis of protein complexes through the use of multiple cross-linkers. Anal Chem. 88(8):4461-9.
7. Lu S?, Fan SB?, Yang B?, Li YX, Meng JM, Wu L, Li P, Zhang K, Zhang MJ, Fu Y, Luo J, Sun RX, He SM*, and Dong MQ*. (2015) Mapping Native Disulfide Bonds at a Proteome Scale. Nature Methods doi: 10.1038/nmeth.3283.
8. Yang B?, Wu YJ?, Zhu M?, Fan SB?, Lin J, Zhang K, Li S, Chi H, Li YX, Chen HF, Luo SK, Ding YH, Wang LH, Hao Z, Xiu LY, Chen S, Ye K, He SM*, and Dong MQ* (2012) Identification of cross-linked peptides from complex samples. Nature Methods 9(9): 904-906

*以上信息由高級會員個(gè)人更新和維護(hù)。